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These potential metabolic benefits have been primarily demonstrated in patients with diagnosed pathological hyperprolactinemia, and dopamine agonists are not recommended for the treatment of obesity in patients with normoprolactinemia

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The primary method for diagnosing MDD follows the American Psychiatric Associations DSM-5 criteria, which require at least five specific symptoms (e.g., depressed mood, loss of interest) to be present over a two-week period

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Moreover, PD-1 expression on exhausted CD8 + T cells is heterogeneous, and heterogeneous PD-1 expression likely affects sensitivity to anti-PD-1 therapy [237]