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Pigott Department of Community Medicine, Employee State Insurance Post Graduate Institute of Medical Sciences and Research, Bangalore, India Sharath Burugina Nagaraja Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan Muhammad Hammad Butt Department of Family and Community Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Nadeem Shafique Butt School of Public Health and Health Systems, University of Waterloo, Waterloo, ON, Canada Zahid A

Lancet Neurol (2014) 13:54556

(2022) 5:e202201417

1 Introduction Diabetic kidney disease (DKD) is a chronic kidney disorder that has become one of the most devastating complications of diabetes worldwide and a leading cause of end-stage renal failure

2018;28:793800.e2

This also results in the opening of the mPTP leading to uncontrolled ROS production and disrupted synaptic maturation causing autistic behaviors [127]