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The FDA first approved it as an appetite suppressant in 1959

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Moreover, since recent studies have shown that the de- and remyelination extend as well the cellular composition seems to differ between white and gray matter MS lesions (Bo et al., 2007) the cuprizone model becomes increasingly attractive to study the underlying pathophysiological mechanisms of de- and remyelination to uncover regional differences (Gudi et al., 2009

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As Talmage wrote, 'Ehrlich considered that selection occurred as a result of natural affinity between antigen and cellular receptors
[DOI] [PMC free article] [PubMed] [Google Scholar] (795).Ozaki T
