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Januvia is a brand-name drug that contains the ingredient sitagliptin

The addition of GIP receptor agonism in tirzepatide does not appear to significantly amplify heart rate effects compared to GLP-1-only drugs like semaglutide

32 Patient adherence to calorie restriction often wanes over time and many patients experience cycles of weight loss and gain

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However, one should be aware of the fact, that GLP-1-RA have a higher incidence of gastrointestinal adverse events like nausea (110, 112, 114), which might be disadvantageous for elderly people who may be more prone to these side effects (114)

Studies are still happening to understand why. The data from Dandelion Health showed that the 10% of people with the best response to GLP-1s had results that mirrored what clinical trials found, but the 10% with the least success with the treatments had no weight change, or even an increase in weight, over time