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NNMT inhibition increases NAD+ levels and enhances sirtuin-mediated mitochondrial function

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Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes

Long-term tiredness often signals b12 shortage

The best time to take B12 for weight loss is usually in the morning to maximize daytime activity and prevent potential sleep disturbances if taken at night

The distinction matters because AOD-9604 preserves lean mass in animal models, and the mechanism of action suggests it does the same in humans