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Description
In a healthy dog, the pancreas, intestines, liver, and kidneys are all needed to properly absorb and store this B12

Aging, smoking, infection, genetic predisposition, abnormal biomechanical loading (such as long-term bending or heavy lifting), and reduced nutrient supply through the cartilage endplate are all inducing factors (Wu et al., 2021)

Understand why it happens

Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses
Mayo Clinic Proceedings: Innovations, Quality & Outcomes

Updated May 23 2019
