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5.3 Post-translational modification regulation of enzyme activity The activity of metabolic enzymes involved in the de novo serine synthesis pathway is precisely modulated by post-translational modifications such as methylation, ubiquitination and deacetylation ( Figure 3 ), and such regulatory patterns exhibit cancer-type specificity

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Proteins involved in protein synthesis were substantially up-regulated in nicotine exposed bees, indicating the induction of proteins directly or indirectly involved in the mechanisms underlying nicotine tolerance (see Table 2 and Supplementary Table 1)

Specifically, six differentially regulated miRNAs (miR-483-5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) have been implicated in PH, indicating their role in the regulation of iron-related pathways [607]

Serotonin selective reuptake inhibitors (SSRIs) are given frequently, the benefit of SSRI treatment in PD has not been established, however (Wermuth and Bech, 2006)

Garnock-Jones KP