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The case series, which included six patients, involved people who had positively screened for alcohol use disorder

Receptor density in cardiovascular and immune tissues is, however, markedly lower than in the pancreas, and the modest physiological increment in GLP-1 produced by DPP-4 inhibition does not appear sufficient to drive the downstream signaling needed for anti-inflammatory, endothelial, or plaque-modifying effects [13], [14], [28]

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By contrast, PD, which also has a prolonged prodromal stage similar to AD before the onset of motor symptoms, has a different progression of Lewy body pathology, which may take another decade to pervade the entire brain and cause significant, widespread neurodegeneration [102]

Results: Within this cohort (mean age 61.62 13.3 years, 61% male), 34.8% of patients demonstrated evidence of large fibre neuropathy