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For instance, declining gait speed, physical function and cognition, mitochondrial aging, elevated inflammation, immune dysfunction, frailty and other health conditions are significantly higher in people with HIV when compared to age- and sex-matched uninfected people

doi: 10.3390/ijms21218113

In the case of copper, increased toxicity is believed to be linked to a coordinated sequence of events (lysosome rupture and/or the reduction of the GSH/GSSG ratio) that induce significant cytotoxicity(Lovejoy et al

Moreover, in renal HEK293 cells NPs treatment increased ROS, MDA and LDH levels, while decreasing ATP production and upregulating inflammatory cytokines TNF and IL-6, along with caspase 3 and 9 gene expression [101]

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