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Its important to choose the right type of B12 for your individual genetics before taking methylfolate to treat the MTHFR gene mutation for depression and anxiety If you have the MTHFR gene mutation and you start supplementing methylfolate When you have the COMT [COMT +/+] your ability to Fully functioning VDR Taq genes are needed to manufacture dopamine and norepinephrine and people with the VDR Taq mutations do not make enough dopamine/norepinephrine