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Translational efforts face an additional barrier: while CSF1R inhibitors allow experimental microglial manipulation, recreating their physiological complexityincluding precise spatial distribution and functional heterogeneitypresents a significant challenge for therapeutic development

[DOI] [PubMed] [Google Scholar] 84.MECCHI E.P., PIPPEN E.L., LINEWEAVER H

This phenotype was confirmed with in vivo larval rearing

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Measurement of intracellular GSH levels Intracellular GSH levels in SH-SY5Y and BV-2 cells were assessed using a GSH assay kit (CS0260, Sigma, Merck KGaA, Darmstadt, Germany)

Clinical trials found no associated increase in arrhythmias or adverse cardiovascular events