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Where does the available human evidence sit on the study design hierarchy: case report (low grade), retrospective series, or controlled trial (higher grade)

At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed

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Loss of vision is also possible, if the optic nerves are affected

1: mild