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While keeping in mind that Mt NR2 is much more expressed than Mt NR1 , these observations strongly suggest that both NR1 and NR2 are involved in the production of NO during the symbiotic process

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AoB Plants 8, plw065

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The TPH1 gene encodes the predominant tryptophan hydroxylase responsible for serotonin synthesis in enterochromaffin cells of the intestines

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Am J Physiol 244(6):E536E540 Wastney ME, Aamodt RL, Rumble WF, Henkin RI (1986) Kinetic analysis of zinc metabolism and its regulation in normal humans

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They also occur from exposure to environmental toxins and pollutants, and from long periods of ongoing stress

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315 , E924E948 (2018)

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