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In a recent metanalysis of 39 studies of functional connectivity during motor tasks, patients with PD consistently showed reduction in activation of the posterior putamen, cerebellum, primary motor cortex and supplementary motor area, but also increased activation to cortical regions connected to the anterior putamen 147

whether these mitochondrial defects represent a cause or a consequence of insulin resistance in skeletal muscle remains to be fully elucidated

A chloroquine dose-response curve was used as control (Supplementary Figure S2D)

These liposomes encapsulate the glutathione, protecting it from degradation and improving its absorption in the gastrointestinal tract

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