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A phase 2 placebo-controlled 2-year clinical trial, with 51 individuals with SPMS enrolled, showed that lipoic acid significantly reduced brain volume atrophy

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10.1158/1078-0432.CCR-09-3191 Clin

Grill et al., 2002) to regulate blood glucose levels (Lam et al., 2005) and insulin signaling (Pocai et al., 2005)

Also, consistent with earlier experiments in parental cell lines, BPM31510 treatment significantly increased G3P-driven ROS production (Fig

[DOI] [PubMed] [Google Scholar] 95.Gardoni F., Morari M., Kulisevsky J., Brugnoli A., Novello S., Pisan C.A., Caccia C., Mellone M., Melloni E., Padoani G., et al