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Although muscle stores more glycogen than the liver, it has no glucose-6-phosphatase and therefore cannot directly contribute glucose to the blood

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Broader solid tumor studies corroborate that pharmacological inhibition of CAF-mediated Gln synthesis disrupts tumor metabolic fitness, suggesting combinatorial targeting of tumoral and stromal glutamine metabolism, particularly through dual GLS1/ECM pathway inhibition, may offer promising therapeutic avenues for advanced prostate cancer (196)