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This work was supported by the National Natural Science Foundation of China (32371255 and 32071203 to LHZ, 32130022 and 82121005 to HEX, 82404881 to QNY)

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Belichenko et al., Since Rett syndrome manifests itself in early postnatal life when experience shapes neuronal circuit wiring, and since Mecp2 is activity-dependently regulated (Cohen et al., 2011), it is hypothesized that Mecp2 might mediate experience-dependent processes of synapse development

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