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2010 PubMed Safety assessment of tripeptide-1, hexapeptide-12, their metal salts and fatty acyl derivatives, and palmitoyl tetrapeptide-7 as used in cosmetics Johnson W et al
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It analyzes pathway-level variants in MTHFR, MTRR, COMT that shape baseline biology the upstream context that applies across all longevity-protocol compounds

3f), and its relative abundance was lowest in WD control mice compared to all other groups
doi: 10.1111/j.1365-2826.2007.01638.x