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The FDA has approved HDAC inhibitors, including SAHA, romidepsin (depsipeptide), and belinostat, for certain cancers such as T-cell lymphoma

(Wan et al., 2016) found that the system could restore the NP phenotype following dedifferentiation through upregulating NP-specific genes ( KRT-8, KRT-18, FOXF-1 ) and the SAPH stimulated time-dependent increases in aggrecan and type II collagen deposition (Figure 7)

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Cleavage of GCLC occurs at Asp 499 within the sequence AVVD 499 G, which lies upstream of Cys 553 that is thought to be important for association with GCLM (Franklin et al., 2002)

Ludvik B, Giorgino F, Jodar E, Frias JP, Fernandez Lando L, Brown K