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however, downregulation of ER is the dominant mechanism of tamoxifen resistance

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The high GSH/GSSG ratio provides the essential reducing environment inside the cell

Rna stability: a review of the role of structural features and environmental conditions

With certain genetic inefficiencies, glutathione production can be reduced 50% or more, and it is estimated that nearly 1 in 3 people has this genetic variant

Additionally, such doses might reduce the efficacy of chemotherapy or radiotherapy by counteracting the oxidative stress needed to target cancer cells [20]