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Abbreviations ACPs anticancer peptides BrdU bromodeoxyuridine CAR chimeric antigen receptor cFLIP cellular FLICE-inhibitory protein COP1 cytosolic dual-specificity phosphatase 1 DFTD Devil facial tumor disease EAC Ehrlich ascites cells EGFR epidermal growth factor receptor ERK extracellular signal-regulated kinase GLOBOCAN Global Cancer Observatory GO Gene Ontology HER2 human epidermal growth factor receptor 2 HLAs human leukocyte antigens HNP-1 to 3 human neutrophil defensins 1-3 HUVECs human umbilical vein endothelial microvascular endothelial cells IAP inhibitor of apoptosis ICIs immune checkpoint inhibitors IL-2 interleukin 2 LDH lactic dehydrogenase MDSCs myeloid-derived suppressor cells MIC minimum inhibitory concentration MSCs mesenchymal stromal cells MTT 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide NCI National Cancer Institute NHL non-Hodgkin lymphoma NK natural killer NPN N -phenyl-1-napthylamine PS phosphatidylserine Saha-CATH1 Sarcophilus harrisii-cathelicidin 1 TAAs tumor-associated cells TAMs tumor-associated macrophages TANs tumor-associated neutrophils TME tumor microenvironment Tregs regulatory T cells VEGFR2 vascular endothelial growth factor receptor 2 WHO World Health Organization WST-1 Wild Type Staining-1 Declarations Acknowledgments Anuradha Sharma and Apurva Sood are thankful to Lovely Professional University for providing the environment in which we conducted this review