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This background suggests that the optimal condition for a drug to be more efficient in carrying out its therapeutic action would be to cross a BBB with good vascular integrity and without further damage in the neuronal functional state

TSH should be checked at every follow-up visit if the patient is on stable thyroid replacement [7]

The investment of time and resources is wasted

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2) The role for oxidative-stress-activated signalling pathways in the pathomechanisms described above, particularly those involving Ca2+ elevation and its consequent activation of Ca2+-dependent PKC isoforms