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Ketamine facilitates extinction of avoidance behavior and enhances synaptic plasticity in a rat model of anxiety vulnerability: Implications for the pathophysiology and treatment of anxiety disorders
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Given the lack of significant evidence, it is unclear if pramipexole and ropinirole are useful in patients after TBI, except in the setting of potential sleep-related movement disorders, such as RLS or TRD

This process, often referred to as target validation , is a foundational step in early drug development
10.1016/j.mce.2008.07.016 [DOI] [PubMed] [Google Scholar] 10.Srinivas-Shankar U, Roberts SA, Connolly MJ, OConnell MD, Adams JE, Oldham JA, Wu FC

Cancer Cell 43 , 13651376 (2025)
