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Description
IM would require daily or every-other-day injections to achieve comparable cumulative fibroblast exposure

It provides a logical explanation for the development of dual targeting drugs such as MM-131 a bispecific anti-MET/EpCAM mAb [108] and also further drug discoveries targeting concurrently all three c-Met, EpCAm and Wnt pathway simultaneously to overcome both innate and acquired resistance to tyrosin kinase inhibitors (TKIs)

Author contributions AA: Formal analysis, Investigation, Project administration, Validation, Writing original draft, Writing review & editing

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G et al

Understanding these nuances separates successful protocols from wasted investments

Other Safety Considerations Several additional safety topics are relevant to the clinical use of orforglipron: Gallbladder events: GLP-1 receptor agonists have been associated with increased rates of cholelithiasis and cholecystitis, likely mediated by rapid weight loss altering bile composition and gallbladder motility
