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Description
Both Y179 4.63 A and F330 6.52 A substitutions cannot be activated by SR146131 as measured by the cAMP accumulation assay

and Fatemi, S.H., Anatomical Record , 2011, vol

Buspirone in the management of anxiety and irritability in children with pervasive developmental disorders: results of an open-label study

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It means the therapy has to match the indication, the patient, and the clinical context
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