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Blood gases, hematology, and renal blood flow during prolonged mountain sojourns at 3500 and 5800 m

It just means that its efficacy is more limited, forcing you to consider supplement timing and meals that can provide additional amino acids

Tindall, D

Research peptides are frequently incorporated into scientific investigations designed to evaluate analytical properties, material characteristics, and comparative performance within controlled laboratory environments

Proc Natl Acad Sci United States America (2014) 111(39):1421722

If you are experiencing side effects without clear benefits, the trade-off does not make sense
