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The signaling cascades and pathways are generally very integrative in nature and are primarily regulated by hormones (Atkinson and Urwin, 2012)
Oxidative stress-induced inflammatory stress response can severely damage the intestinal epithelium, which is a single layer at the luminal interface of the organism

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10.14814/phy2.13982 [DOI] [PMC free article] [PubMed] [Google Scholar] Wightman, E

Moreover, exhausted T cells are enriched in tumor-reactive clones [217, 218]
By Iglesias C, Nelson EA, Cullum NA, Torgerson DJ, on behalf of the VenUS Team
