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In diseases such as prion disorders, it has been shown that microglial activation may contribute to disease progression through the release of proinflammatory mediators [33,34]

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475,480,481 The encouraging results obtained with semaglutide in patients with heart failure and a preserved ejection fraction may provide a new option for this patient population, in which additional therapy, as well as another upstream therapy for patients with a higher BMI who have indications for this condition, is urgently needed