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Rosen et al, 1999)
AML cells, due to their hypoxic microenvironment in the bone marrow, are more susceptible to ROS than other cancer cells [19, 20]
[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Roth R.A., Maiuri A.R., Ganey P.E
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Furthermore, redox-active metals like copper and iron can catalyze the Fenton reaction, generating substantial amounts of ROS, which in turn induces OS and ultimately leads to cell death
Wang X, Simayi A, Fu J, Zhao X, Xu G
