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Glutathione efficiently scavenges free radicals and other ROS (OH, lipid peroxyl radical, peroxynitrites and H 2 O 2 ), directly or indirectly, while oxidizing glutathione to GSSG.[27] By donating H 2 , it helps to destroy H 2 O 2 and other peroxides in cells, which are catalyzed by containing GSHPX.[9,27] The reaction given below is catalyzed by GSHPX as follows:[120,121] 2GSH + H 2 O 2 2GSSH + 2H 2 O Rotruck et al .[122] recognized that the selenium (as an active site selenocysteine residue)[119] is a structural constituent of the active center of the animal enzyme GSHPX-1

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