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Nature (2015) 527(7577):18691

This leads to the accumulation of lactic acid

REFERENCES 1 AdamJ.HatipogluE.OFlahertyL.TernetteN.SahgalN.LockstoneH.et al (2011)

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MANF antagonizes nucleotide exchange by the Endoplasmic reticulum chaperone bip

Dysfunctional mitochondria generate excessive reactive oxygen species (ROS), perpetuating a vicious cycle that further aggravates neurotoxicity (Yan et al., 2021
