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Toxicity increases as particle size decreases, because small particles are more readily taken up by gastric epithelial cells, leading to oxidative stress and mitochondrial dysfunction [47]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Pareek V, Tian H, Winograd N & Benkovic SJ Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

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This can contribute to endothelial dysfunction, making arteries less responsive and creating conditions that favor inflammation and plaque formation