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A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification
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Risk of ESRD and Mortality in Kidney and Bladder Stone Formers

The antiatherogenic functions of Lp-PLA 2 are attributed to its role in hydrolyzing and inactivating the powerful proinflammatory lipid, PAF
