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Importantly, FOXO4-DRI showed no significant toxicity towards normal TM3 Leydig cells, demonstrating its selective action against senescent cells

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Reducing by half and staying at the lower level for four weeks before retrying is a safe approach

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However, it still has significant drawbacks due to the high resource demands required for its execution that limit its application, e.g., to deterministic runs instead of (or limited to small) ensemble runs