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Immunosenescence, a process of immune system dysregulation, causes the elderly to produce low-affinity immunoglobulins at an increased rate, leading to elevated serum levels of IgG1 and IgG4 (124)

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VACV secretes approximately 100 immunomodulatory proteins that neutralise cytosolic nucleic acid sensors such as cGAMP synthase, along with several other antiviral response pathways 39