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Protein Homeostasis Dysregulation Under pathological conditions, syn, a natively unfolded presynaptic protein, misfolds and aberrantly aggregates into toxic oligomeric and fibrillar species

Macak, University of Pardubice, Czechia Reviewed by Darakhshan Javaid, Baba Ghulam Shah Badshah University, India Jignesh Rohit, National Institute of Technology, India Updates Copyright 2026 Kumarasamy, Natarajan, Mathivanan, Balasubramaniam, SN, Prabhu, Raju, Mironescu and Mironescu

These exosomes induced apoptosis in GBM cells and exhibited dose-dependent antitumor activity

This was done by two independent reviewers

However, clinical outcomes have been mixed: a phase II randomized controlled trial (RCT) in early-onset PD patients showed that short-term DFP treatment was safe but only trended toward motor improvement (Martin-Bastida et al., 2017)

Experimental investigations from cellular cultures found the activation of NRF-2 by high doses of glucose, but there was variability between type of cellular pedigree and time of exposure [9193]