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Unlike other antioxidants that come from food, glutathione is not found directly in food but is produced by the body especially in the liver and must be reassembled starting from cysteine, glycine and glutamine as the final product of the sulphation process

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Consistent with IL-15s role in promoting mitochondrial respiration, dampening glycolysis, and maintaining stemness of CD8 T cells, overexpression of FoxO1 in CART cells significantly enhances mitochondrial respiration and reduces the expression of exhaustion-related genes [48]