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However, it is suggested that high concentration (in micro-molars) of NO may induce apoptosis in cancer cells by damaging DNA, although there is no corresponding clinical observation [117, 118]

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In silico docking confirmed strong binding affinity of PDSE-derived rutin and quercetin with caspase-3, further supporting their role in apoptosis induction ( Mangifera pajang (a lesser-known mango species) kernel extract showed cytotoxicity in both hormone-dependent (MCF-7) and triple-negative (MDA-MB-231) BC cells, with IC50 values of 23 g/mL and 30.5 g/mL, respectively