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Instead of being recycled from NAM emanating from NAD+ consumption, NR gets converted into NMN inside the cell by an enzyme family called nicotinamide riboside kinases (NRKs)

Thorne's WPI provides 21 grams per serving, hitting this therapeutic window perfectly

Ghosh et al., 2015), which in turn triggers the exchange of GDP for GTP by the G proteins

GSSG is subsequently reduced by glutathione reductase (GR) in the presence of NADPH, the consumption of which is measured spectrophotometrically

Apart from clinical efficacy defined as the change in Hamilton Depression Rating Scale (HAMD)-17 score, secondary outcomes include changes in pathophysiological mechanisms related to depression as well as changes in local brain activity (functional Magnetic Resonance Imaging, fMRI) and white matter integrity (Diffusion Tensor Imaging, DTI)

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