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Subsequent subregion analyses showed that the ventral tegmental area as well as subregions of the amygdala displayed enhanced activity patterns after GLP-1MK-801 treatment (Extended Data Fig

The prevalence of pruritus varies depending on the underlying cause, with reports indicating rates of up to 70% in primary biliary cholangitis, 2.530% in chronic hepatitis C virus-related liver disease, and roughly 8% in cirrhosis attributed to hepatitis B virus infection ( Numerous hypotheses have been posited to elucidate the genesis of pruritus, albeit none deemed definitive