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It is important to use a model where NAC (at the doses used) has a clear inhibitory effect on ethanol intake, such that a possible association with neuroinflammation or oxidative stress can be investigated

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It is formed by reverse splicing of pre-mRNA, and some circRNAs are abundant and evolutionarily conserved (Misir et al., 2022)

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For example, oral administration of 300 mg of glutathione daily for 4 months to non-alcoholic fatty liver disease patients demonstrated a potential therapeutic effect of GSH, as indicated by a decline in the liver enzyme ALT [82]

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The liver breaks down alcohol, but the process can generate harmful substances that damage liver cells and promote inflammation

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