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Glucose starvation damages the glycolysis and pentose phosphate pathways, leading to an increase in reactive oxygen species (ROS) production and damage to the antioxidant system, resulting in oxidative stress, redox imbalance, and cell death (Ren and Shen, 2019)

The main molecular trigger of these events appears to be NADPH oxidation by NOX, which stimulates oxPPP flux 11

Sallustio BC, Nunthasomboon S, Drogemuller CJ, Knights KM

1 2 "'It's not about lifespan': meet the man who believes biohacking is a holy duty"

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Rising demand for GLP-1 drugs despite their high price also presents barriers to access