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Indigestible fragments of gluten are able to bind CXCR3 and release zonulin.[13] Studies have shown that elevated serum zonulin levels increased in obese versus non-obese subjects, and there is evidence of a correlation between total bacteria and serum zonulin levels, suggesting that the gut microbiota may cause increased zonulin levels, and subsequent abnormal gut permeability to endotoxin and ultimately micro-inflammation has been reported in obesity.[14] A qualitative and quantitative imbalance in the composition of the intestinal microbiota or dysbiosis contributes to intestinal barrier dysfunction and leaky gut syndrome

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Do not use on broken, irritated, or sensitive skin

Research has shown that many alkaloids have qualities that alleviate pain