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On the other hand, a 2:2 complex between HGF and Met in which the dimerization interface is provided by two HGF molecules has been proposed for Met activation 6

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The proposed mechanism involves MMP-1, a specific matrix metalloproteinase

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10.1016/j.bbi.2012.09.004 [DOI] [PMC free article] [PubMed] [Google Scholar] Leo R, Apolnio JD, Lee D, Figueiredo A, Tabori U, Castelo-Branco P (2018) Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer