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Increased -amyloid (A) levels associated with AD have been shown to promote oxidative stress in the brain, leading to loss of peroxisomal function

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Additionally, ACEIs and ARBs directly counteract the toxic uremic effects of TMAO, which normally downregulates the expression of megalin, a crucial protein in renal albumin handling

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doi: 10.1038/s41467-017-00900-1 7
