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Leaner individuals or those injecting in areas with less subcutaneous fat may prefer 8mm (5/16 inch) needles to avoid intramuscular injection

Evidence also suggests that substrate channeling occurs between a metabolic unit (termed branched-chain amino acid metabolon) consisting of human BCAT m and BCKADHC and that the channeling is influenced by the redox state in mitochondria (Islam et al., 2007, Islam et al., 2010)

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These changes are called dysplasia and may be described as 'pre-cancerous'

Protocols vary, but some practitioners recommend injections every 2-3 days instead of daily, adjusting the dose accordingly

Stay at least two inches (around 5cm) clear of the navel, which the NHS guidance recommends avoiding