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Preclinical and clinical studies demonstrate that AX enhances skeletal muscle metabolism by stimulating mitochondrial biogenesis, promoting fatty acid oxidation, and reducing lipotoxicity under metabolic stress conditions [7,8,9]

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Role of nitric oxide in methamphetamine neurotoxicity :protection by 7-Nitroindazole, an inhibitor of neuronal nitric oxide synthase

In the FSL rats, a combined treatment with sodium salicylate, which is a non-selective inhibitor of NF-B, counteracted the antidepressant effect of LAC on the expression of mGlu2 receptors, supporting the link between LAC-mediated mGlu2 induction and p65/NF-B [30]