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Luteolin, from Folium perillae and Flos lonicerae , was found to reduce phosphodiesterase 4 (PDE-4), thus lowering cyclic AMP (cAMP) hydrolysis and preventing neutrophil adhesion and cytokine release (Jiang et al

Zhou, Y., Yang, Y., Huang, J., Jiang, S

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This modification of tyrosine can also come from the nitrogen dioxide radical (NO2), which is formed by the reaction of hypochlorous acid (HOCl) and nitrite (NO2-)

Biologics (such as belimumab) can be used in non-reactive cases but shows variable responses