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Importantly, the triple-helix conformation demonstrates superior radical-quenching efficacy, with significantly elevated antioxidant activity across standardized assays: DPPH (IC 50 = 2.498 mg/mL), ABTS (IC 50 = 3.413 mg/mL), FRAP (44.73 2.88 mol Fe 2+ /g), and ORAC (47.09 5.68 mol TE/g)

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The above studies demonstrate that natural compounds such as ginsenoside Rb1, CSE, and menthol protect dopaminergic neurons and reduce neuroinflammation by inhibiting the over-activation of microglia and astrocytes and reducing the release of pro-inflammatory cytokines and neurotoxic factors

457,458 ZIP4, in particular, has been shown to regulate the expression of MMP2 and MMP9, influencing zinc concentration and promoting invasiveness and migration of hepatoma cells

CHAC1 amplifies this oxidative cascade by degrading residual GSH, further elevating ROS levels and preventing GPX4-mediated detoxification

Front Biosci (landmark Ed) 18(2):685695