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10.1007/s11745-000-0618-7

A laxative effect may occur in case of overdose

designed the thienopyridine skeleton ( Figure 18 ) and optimized this type IKK inhibitor through the modification of R 1 and R 2 substituent groups [183]

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Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality, with wellestablished risk factors including hypertension, dyslipidemia, obesity, diabetes mellitus, and smoking [5]